Adrenal tumors, pituitary tumors, and other pathological changes in F hybrids of strain DE x strain DBA.

Neonatal gonadeetomy has been used in some inbred strains of mice (7, 8, 10, 13-17) as an experimental tool to study the effect of hormonal imbalance. ~I'he effect of neonatal gonadectomy in reciprocal hybrid mice of several inbred strains has been described (11, 1~). This paper will report the response to gonadectomy of the F1 animals of strain DE X strain DBA and will compare the response of this hybrid with the response of F1 animals of strain CE X strain DBA (11). Strain DE, an inbred strain phenotypically identical with strain C E / W y and, like strain CE, exhibiting a poor breeding record, was originated by Eaton from a cross of the E strain with strain CE. Offspring with the extreme dilution color were selected and inbred (6). Adrenal cortical carcinomas occur in 100 per cent of CE gonadectomized mice (13-17) but have not been observed in DE gonadectomized animals, x